PolyCap TC 36 PES Capsule Filter SKU: 6714-3604

Polyethersulfone (PES) Capsule Filters - 6714-3604

Ultra-low protein binding and broad pH compatibility from 1 to 14 make PES capsule filters the preferred membrane choice for processing biological solutions at production scale. At its core, PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. The outcome is a validated filtration barrier that arrives ready for process integration, supporting the single-use manufacturing strategies adopted by modern pharmaceutical and biotechnology facilities.

Key Polyethersulfone (PES) Membrane Characteristics

• PES membrane capsules deliver broad pH compatibility from 1 to 14, accommodating the full range of buffers, media, and cleaning solutions encountered in biopharmaceutical processing.
• The built-in prefilter layer eliminates the need for a separate upstream guard filter, reducing both the number of devices in the fluid path and total system holdup volume.
• PES membrane construction supports integrity testing by forward flow, bubble point, or pressure decay methods, providing the post-use verification required by pharmaceutical quality systems.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.

Key Capsule Construction Features

• Barbed inlet and outlet connections provide a practical, leak-resistant interface for gravity-feed, peristaltic pump, and pressure-driven filtration systems using flexible tubing.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.

Whether your process requires sterilizing-grade retention for a 500-milliliter bench trial or clarification capacity for a 100-liter production batch, the right capsule filter configuration eliminates the compromises between throughput, retention, and operational simplicity. With this in mind, if your process involves aqueous biologicals, the ultra-low protein binding and broad pH compatibility of PES membrane construction protect your product while sustaining the flow rates your batch schedule requires. Take control of your sample preparation variables and ensure that your data reflects the true nature of your work, rather than the quality of your consumables.

Sterilization Guidance

Validated sterility from the point of manufacture through the labeled shelf life allows immediate deployment in critical filtration steps without additional sterilization procedures.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

30 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 36

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

3.6 cm

Filling Bell (Yes/ No)

No

Filtration Area

550 cm²

Holdup Volume

70 mL

Inlet Connection

1/4 to 3/8 in. stepped barb

Material

PES

Max Batch Volume

Medium-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

1/4 to 3/8 in. stepped barb

Pack Count

1

Pore Size (µm)

0.45

Pre-filter Pore Size

0.65

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.