Polyethersulfone (PES) Capsule Filters - 6714-6004
Ultra-low protein binding and broad pH compatibility from 1 to 14 make PES capsule filters the preferred membrane choice for processing biological solutions at production scale. Constructed for reliable operation, the pleated PES membrane pack maximizes effective filtration area within the capsule housing, sustaining high flow rates through large batch volumes while inherent hydrophilicity ensures immediate wetting without alcohol pre-treatment. By design, the result is a filtration workflow that scales efficiently from method development through production, delivering consistent retention performance across the full range of capsule effective filtration areas.
Key Polyethersulfone (PES) Membrane Characteristics
- Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
- The 121 degree Celsius temperature limit ensures reliable capsule performance for ambient and moderately heated filtration applications.
- Non-sterile capsule delivery is appropriate for clarification, prefiltration, and general laboratory applications where the filtrate does not require sterility assurance.
- The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.
- The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.
Key Capsule Construction Features
- Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
- The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.
- Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
- Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. For this application, for laboratories processing cell culture media, buffers, or biological preparations, PES capsule construction delivers the combination of low binding, high throughput, and validated retention that your quality system depends on. Secure your research outcomes by partnering with a filtration solution that understands your need for speed, accuracy, and reproducibility.
Sterilization Guidance
Supplied non-sterile, the polypropylene housing supports autoclave sterilization at 121 degrees Celsius for 20 minutes when aseptic filtration is required by the application protocol.
For more information about chemical compatibility, please review our Chemical Compatibility Chart.
- Burst Pressure (psi)
- 60 psi
- Capsule Format
- Polycap GW 75
- Compliance Standards
- ISO 9001
- Construction
- Polypropylene
- Diameter
- 7.5 cm
- Filling Bell (Yes/ No)
- No
- Filtration Area
- 920 cm²
- Flow Rate
- 0.015 L/min
- Holdup Volume
- 22 mL
- Inlet Connection
- 1/2 in. stepped barb
- Length
- 13.7 cm
- Material
- PES
- Max Batch Volume
- Large-volume batch processing
- Maximum Operating Pressure
- 60 psi
- Maximum Operating Temperature (°C)
- 121 °C
- Outlet Connection
- 1/2 in. stepped barb
- Pack Count
- 1
- Pore Size (µm)
- 0.45
- Prefilter (Yes/No)
- No
- Sterility
- Nonsterile
- Sterilization
- Autoclave
- Vent (Yes/ No)
- No
- Wettability
- Hydrophilic
- Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
- Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
- Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
- Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
- Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
- Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.