PolyCap TC 75 PES Capsule Filter SKU: 6714-7501

Polyethersulfone (PES) Capsule Filters - 6714-7501

When processing aqueous biologicals at volumes beyond syringe filter capacity, PES capsule filters provide the throughput and recovery performance that bench-scale devices cannot match. PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. The outcome is higher operational throughput with lower contamination risk, as disposable capsule devices remove the reprocessing steps that introduce variability into reusable filter systems.

Key Polyethersulfone (PES) Membrane Characteristics

• The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.
• Rated for continuous operation at temperatures up to 121 degrees Celsius, the capsule maintains structural integrity and retention performance across the normal process temperature range.
• The 60 psi maximum pressure rating accommodates the differential pressures generated during filtration of particle-laden solutions as the membrane progressively loads.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• Integrated prefiltration within the capsule distributes particle loading across two membrane layers, preventing the rapid fouling that occurs when high-particulate feeds contact a single sterilizing-grade membrane.

Key Capsule Construction Features

• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• Stepped hose barb design accommodates multiple tubing sizes on a single fitting, simplifying inventory management and enabling connection flexibility across different process configurations.
• Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. For applications like these, if your process involves aqueous biologicals, the ultra-low protein binding and broad pH compatibility of PES membrane construction protect your product while sustaining the flow rates your batch schedule requires. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Sealed sterile packaging preserves validated sterility throughout storage and transport, providing a documented sterile barrier that is ready for use at the point of need.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

46 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 75

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

7.5 cm

Filling Bell (Yes/ No)

No

Filtration Area

1100 cm²

Holdup Volume

125 mL

Inlet Connection

1/4 to 3/8 in. stepped barb

Material

PES

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

1/4 to 3/8 in. stepped barb

Pack Count

1

Pore Size (µm)

0.1

Pre-filter Pore Size

0.2

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.