PolyCap TC 75 PES Capsule Filter SKU: 6714-7502

Polyethersulfone (PES) Capsule Filters - 6714-7502

PES capsule filters address the growing demand for single-use, validated filtration devices that integrate directly into pharmaceutical and biopharmaceutical fluid transfer systems. Manufactured to exacting specifications, asymmetric PES membrane construction captures contaminants at the upstream surface while maintaining open pore channels beneath, extending capsule service life and reducing the frequency of mid-batch device changes. The outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key Polyethersulfone (PES) Membrane Characteristics

• PES membrane capsules deliver broad pH compatibility from 1 to 14, accommodating the full range of buffers, media, and cleaning solutions encountered in biopharmaceutical processing.
• Dual-layer membrane construction combines a coarser upstream prefilter with a finer downstream retention membrane, maximizing dirt-holding capacity within a single capsule device.
• PES capsule filters achieve flow rates that support large-batch processing without the mid-run device changes that disrupt sterile workflows and introduce contamination risk.
• Rated for operating pressures up to 60 psi, the capsule housing withstands the system pressures encountered in peristaltic pump, pressure vessel, and gravity-feed filtration configurations.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.

Key Capsule Construction Features

• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
• Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

When your filtration protocol calls for a validated, integrity-testable barrier that arrives ready to connect and begins filtering immediately, the capsule format delivers that capability without the overhead of traditional filter assemblies. When your filtration protocol demands both validated retention and maximum product recovery, PES membrane architecture balances performance with the low-adsorption surface chemistry your biologics require. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Factory sterilization ensures the device is ready for immediate use in aseptic applications, with validated sterility maintained through the sealed packaging until the labeled expiration date.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

40 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 75

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

7.5 cm

Filling Bell (Yes/ No)

No

Filtration Area

1100 cm²

Holdup Volume

125 mL

Inlet Connection

1/4 to 3/8 in. stepped barb

Material

PES

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

1/4 to 3/8 in. stepped barb

Pack Count

1

Pore Size (µm)

0.2

Pre-filter Pore Size

0.2

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.