PolyCap TC 75 PES Capsule Filter SKU: 6715-7502

Polyethersulfone (PES) Capsule Filters - 6715-7502

PES capsule filters address the growing demand for single-use, validated filtration devices that integrate directly into pharmaceutical and biopharmaceutical fluid transfer systems. Furthermore, asymmetric PES membrane construction captures contaminants at the upstream surface while maintaining open pore channels beneath, extending capsule service life and reducing the frequency of mid-batch device changes. Ultimately, the result is a filtration workflow that scales efficiently from method development through production, delivering consistent retention performance across the full range of capsule effective filtration areas.

Key Polyethersulfone (PES) Membrane Characteristics

• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.
• The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.
• Internal holdup volume of 125 milliliters minimizes sample loss during capsule filtration, a critical consideration when processing expensive biologics or limited-volume preparations.
• PES capsule filters achieve flow rates that support large-batch processing without the mid-run device changes that disrupt sterile workflows and introduce contamination risk.

Key Capsule Construction Features

• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

Whether your process requires sterilizing-grade retention for a 500-milliliter bench trial or clarification capacity for a 100-liter production batch, the right capsule filter configuration eliminates the compromises between throughput, retention, and operational simplicity. To address this, when your filtration protocol demands both validated retention and maximum product recovery, PES membrane architecture balances performance with the low-adsorption surface chemistry your biologics require. Secure your research outcomes by partnering with a filtration solution that understands your need for speed, accuracy, and reproducibility.

Sterilization Guidance

Validated sterility from the point of manufacture through the labeled shelf life allows immediate deployment in critical filtration steps without additional sterilization procedures.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

40 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 75

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

7.5 cm

Filling Bell (Yes/ No)

Yes

Filtration Area

1100 cm²

Holdup Volume

125 mL

Inlet Connection

1/4 to 3/8 in. stepped barb

Material

PES

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

1/4 to 3/8 in. stepped barb

Pack Count

1

Pore Size (µm)

0.2

Pre-filter Pore Size

0.2

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.