PolyCap TC 75 Capsule Filter, 0.6/0.45um, Sterile, w/ 1/2in SB Inlet & Outlet SKU: 6717-7504

Polyethersulfone (PES) Capsule Filters - 6717-7504

Ultra-low protein binding and broad pH compatibility from 1 to 14 make PES capsule filters the preferred membrane choice for processing biological solutions at production scale. From a technical standpoint, PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. In practice, the outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key Polyethersulfone (PES) Membrane Characteristics

• The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.
• The built-in prefilter layer eliminates the need for a separate upstream guard filter, reducing both the number of devices in the fluid path and total system holdup volume.
• PES membrane construction supports integrity testing by forward flow, bubble point, or pressure decay methods, providing the post-use verification required by pharmaceutical quality systems.
• Capsule holdup volume of 125 milliliters represents the fluid retained within the device after filtration, an important factor when calculating yield for high-value pharmaceutical products.
• Rated for continuous operation at temperatures up to 121 degrees Celsius, the capsule maintains structural integrity and retention performance across the normal process temperature range.

Key Capsule Construction Features

• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
• Stepped hose barb connections accommodate tubing with inner diameters from 1/4 to 1/2 inch, providing secure push-fit attachment without requiring clamps or specialized fittings.

When your filtration protocol calls for a validated, integrity-testable barrier that arrives ready to connect and begins filtering immediately, the capsule format delivers that capability without the overhead of traditional filter assemblies. For laboratories processing cell culture media, buffers, or biological preparations, PES capsule construction delivers the combination of low binding, high throughput, and validated retention that your quality system depends on. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Factory sterilization ensures the device is ready for immediate use in aseptic applications, with validated sterility maintained through the sealed packaging until the labeled expiration date.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

30 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 75

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

7.5 cm

Filling Bell (Yes/ No)

No

Filtration Area

1100 cm²

Holdup Volume

125 mL

Inlet Connection

3/8 to 1/2 in. stepped barb

Material

PES

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

3/8 to 1/2 in. stepped barb

Pack Count

1

Pore Size (µm)

0.45

Pre-filter Pore Size

0.65

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.