PolyCap TC 150 PES Capsule Filter SKU: 6717-9504

Polyethersulfone (PES) Capsule Filters - 6717-9504

When processing aqueous biologicals at volumes beyond syringe filter capacity, PES capsule filters provide the throughput and recovery performance that bench-scale devices cannot match. Developed with critical workflows in mind, PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. To this end, the outcome is a validated filtration barrier that arrives ready for process integration, supporting the single-use manufacturing strategies adopted by modern pharmaceutical and biotechnology facilities.

Key Polyethersulfone (PES) Membrane Characteristics

• Maximum operating pressure of 60 psi provides the differential pressure capacity needed for sustained filtration of viscous solutions and high-flow process streams.
• Integrated prefiltration within the capsule distributes particle loading across two membrane layers, preventing the rapid fouling that occurs when high-particulate feeds contact a single sterilizing-grade membrane.
• PES membrane construction supports integrity testing by forward flow, bubble point, or pressure decay methods, providing the post-use verification required by pharmaceutical quality systems.
• The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.
• PES capsule filters achieve flow rates that support large-batch processing without the mid-run device changes that disrupt sterile workflows and introduce contamination risk.

Key Capsule Construction Features

• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Barbed inlet and outlet connections provide a practical, leak-resistant interface for gravity-feed, peristaltic pump, and pressure-driven filtration systems using flexible tubing.
• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. For this purpose, if your process involves aqueous biologicals, the ultra-low protein binding and broad pH compatibility of PES membrane construction protect your product while sustaining the flow rates your batch schedule requires. Take control of your sample preparation variables and ensure that your data reflects the true nature of your work, rather than the quality of your consumables.

Sterilization Guidance

Pre-sterilized packaging delivers the device ready for direct integration into aseptic workflows, eliminating the preparation time and validation requirements associated with user-performed sterilization.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

30 psi

Burst Pressure (psi)

60 psi

Capsule Format

Polycap TC 150

Compliance Standards

ISO 9001; HIMA Challenge Test

Construction

Polypropylene

Diameter

15 cm

Filling Bell (Yes/ No)

No

Filtration Area

2200 cm²

Holdup Volume

250 mL

Inlet Connection

3/8 to 1/2 in. stepped barb

Material

PES

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

121 °C

Outlet Connection

3/8 to 1/2 in. stepped barb

Pack Count

1

Pore Size (µm)

0.45

Pre-filter Pore Size

0.65

Prefilter (Yes/No)

Yes

Sterility

Sterile

Sterilization

Do not re-sterilize (autoclavable if sterility expires)

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.