MCE Circle ME Range (ME 25), Plain, 0.45um Pore Size, 100mm, 50pk SKU: 10401621

Mixed Cellulose Ester (MCE) Membrane Filters - 10401621

The Whatman 10401621 protects sensitive instrumentation and sample integrity by providing reliable particulate removal with minimal analyte adsorption or background interference. At its core, reproducible separation characteristics define the membrane structure, protecting downstream instruments and preserving sample integrity throughout the filtration process. Because of this, controlled production conditions produce membranes with documented pore size distribution and thickness tolerances, supporting method reproducibility across multiple filter lots.

Material Specifications

• The biologically inert blend of cellulose acetate and cellulose nitrate provides a membrane surface optimized for organism capture and colony enumeration in microbiological assays.
• Hydrophilic by nature, the MCE membrane structure supports high non-specific adsorption for effective organism capture.
• Low tare weight and complete solubility in organic solvents make MCE the standard membrane for gravimetric particulate analysis where method specifications demand minimal blank correction.
• Mixed Cellulose Ester membranes combine cellulose acetate and cellulose nitrate polymers to deliver a smoother, more flexible membrane surface than pure cellulose nitrate.
• Feature a uniform pore structure that provides consistent flow rates and high throughputs across the full range of standard pore size ratings.

Whether your method calls for gravimetric analysis, particle visualization, or microbial enumeration, the pore consistency and surface uniformity documented above ensure that your results reflect the sample — not the filter. For applications like these, MCE's well-documented retention characteristics at standard pore ratings make it straightforward to specify in your method documentation, supporting the reproducibility and traceability that regulated workflows demand. Secure your research outcomes by partnering with a filtration solution that understands your need for speed, accuracy, and reproducibility.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

35.0psi

Color

white

Diameter

100mm

Extractables

low

Filtration Area

78.54cm²

Flow Rate

60ml (Water)

Grid (Yes/No)

No

Material

Mixed Cellulose Esters (MCE)

Maximum Operating Pressure

Holder-dependent

Maximum Operating Temperature (°C)

130°C

Membrane Thickness (µm)

135um

Pack Count

50

pH Range

4-8

Pore Size (µm)

0.45

Sterility

Nonsterile

Sterilization

Autoclavable at 121°C for 30 mins

Support Material

None

Wettability

Hydrophilic

• Yeast & Mold Monitoring - Optimized for the recovery of larger fungal organisms in beverage testing, providing a clear background for ID.
• Gravimetric Analysis - Maintains structural integrity during filtration and drying, providing precise weight measurements of retained particulates.
• Biochemical Assays - High electrostatic properties effectively bind proteins and macromolecules, supporting various diagnostic and research assays.
• Chemotaxis Assays - Acts as a barrier in Boyden chambers, allowing cells to migrate through defined pores towards a chemoattractant source.
• Bioburden Monitoring - Routine testing of pharmaceutical water loops to ensure bioburden levels remain within safe production specifications.
• Aqueous Filtration - Biologically inert composition provides high flow rates and consistent reliability for routine laboratory fluid processing.