AcroPak 200 Capsule w/ Fluorodyne II Membrane - 0.2um, Gamma-Irradaited (3/Pkg) SKU: 12069

PVDF Capsule Filters - 12069

Hydrophilic PVDF capsule filters combine low extractable profiles with validated retention to meet the demands of regulated pharmaceutical manufacturing environments. Hydrophilic PVDF membrane within the capsule housing combines ultra-low protein binding with validated bacterial retention, preserving active pharmaceutical ingredients while removing microorganisms from production fluid streams. The outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key PVDF Membrane Characteristics

• PVDF membrane capsules combine ultra-low protein binding with broad chemical compatibility, balancing sample recovery with resistance to the pharmaceutical solvents encountered in formulation processing.
• PVDF capsule filters maintain consistent retention and flow performance across the operating pressure and temperature ranges encountered in standard pharmaceutical manufacturing conditions.
• Hydrophilic PVDF membrane surfaces minimize non-specific adsorption of proteins, preservatives, and active pharmaceutical ingredients, protecting formulation potency through the filtration step.
• PVDF capsule filters generate low extractable levels compatible with parenteral, ophthalmic, and other regulated dosage form applications.
• The 60 psi maximum pressure rating accommodates the differential pressures generated during filtration of particle-laden solutions as the membrane progressively loads.

Key Capsule Construction Features

• Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Stepped hose barb design accommodates multiple tubing sizes on a single fitting, simplifying inventory management and enabling connection flexibility across different process configurations.

Whether your process requires sterilizing-grade retention for a 500-milliliter bench trial or clarification capacity for a 100-liter production batch, the right capsule filter configuration eliminates the compromises between throughput, retention, and operational simplicity. For exactly this reason, when your filtration step must protect both product purity and product potency, PVDF membrane chemistry delivers the low-binding performance your sensitive formulations require. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

46 psi

Burst Pressure (psi)

60 psi

Capsule Format

AcroPak 200

Compliance Standards

USP Class VI <88>; Endotoxin < 0.25 EU/mL (LAL)

Construction

Polypropylene

Diameter

6.7 cm

Filling Bell (Yes/ No)

Yes

Filtration Area

200 cm²

Flow Rate

0.24 L/min at 0.1 bar

Holdup Volume

≤6 mL

Inlet Connection

1/4 to 1/2 in. stepped hose barb

Length

10.5 cm

Material

PVDF

Max Batch Volume

20 L

Maximum Operating Pressure

60 psi

Maximum Operating Temperature (°C)

60 °C

Membrane Brand

Fluorodyne II

Outlet Connection

1/4 to 1/2 in. stepped hose barb with filling bell

Pack Count

3

Pore Size (µm)

0.2

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclave

Vent (Yes/ No)

Yes

Wettability

Hydrophilic

• Formulation Processing - Low-binding capsule filtration for pharmaceutical preparations where maintaining labeled potency is essential.
• Protein Solutions - Capsule filtration of protein-containing solutions with ultra-low adsorptive losses across the fluid path.
• Biological Products - Membrane processing of sera, biological extracts, and therapeutic proteins with minimal non-specific adsorption losses.
• Preservative Sensitive - Filtration of formulations containing benzalkonium chloride and other preservatives susceptible to membrane binding.
• Diagnostic Reagents - Filtration of sensitive diagnostic solutions where binding-related concentration changes affect assay performance.
• Drug Filtration - Ultra-low binding membrane filtration of pharmaceutical formulations where preservative and API recovery are critical.