AcroPak 20 Filters w/ Fluorodyne II Membrane - 0.2um, Gamma-Irradiated , 3Pk SKU: 12201

PVDF Capsule Filters - 12201

When formulation integrity depends on minimizing membrane interactions, PVDF capsule filters deliver the adsorption performance that protects active ingredient concentrations through filtration. The modified PVDF membrane surface minimizes adsorptive losses of proteins, preservatives, and active compounds, making the capsule format particularly suited to processing sensitive pharmaceutical and biological formulations. As a result, the result is a filtration process that eliminates cleaning validation, reduces changeover time, and provides batch-to-batch consistency through factory-tested, integrity-verified devices.

Key PVDF Membrane Characteristics

PVDF capsule filters maintain consistent retention and flow performance across the operating pressure and temperature ranges encountered in standard pharmaceutical manufacturing conditions.
PVDF membrane capsules combine ultra-low protein binding with broad chemical compatibility, balancing sample recovery with resistance to the pharmaceutical solvents encountered in formulation processing.
Rated for operating pressures up to 60 psi, the capsule housing withstands the system pressures encountered in peristaltic pump, pressure vessel, and gravity-feed filtration configurations.
Hydrophilic PVDF membrane surfaces minimize non-specific adsorption of proteins, preservatives, and active pharmaceutical ingredients, protecting formulation potency through the filtration step.
The low-binding PVDF membrane surface reduces the filter-related losses that become significant when processing low-concentration or high-value pharmaceutical formulations at production scale.

Key Capsule Construction Features

Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.

As batch volumes and regulatory expectations continue to grow, your capsule filter selection becomes a process design decision that affects sterility assurance, product recovery, and operational cost per liter filtered. In these cases, if your formulation contains preservatives, low-concentration APIs, or binding-sensitive biologics, the ultra-low adsorption characteristics of PVDF membrane construction preserve your product's potency through filtration. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.