AcroPak 400 Capsules w/ Supor EKV Membrane - 0.2um, 2.5 - 3.8cm, Gamma-Irradiated , 1/Pk SKU: 12460

Supor (PES) Capsule Filters - 12460

Backed by comprehensive manufacturer validation data, Supor PES capsule filters support the documentation requirements of pharmaceutical and biotechnology production environments. Supor membrane technology within the capsule housing achieves ultra-low protein adsorption levels that preserve biologics throughout sterile filtration, supported by drug master file registrations and extensive biocompatibility data. The result is a filtration process that eliminates cleaning validation, reduces changeover time, and provides batch-to-batch consistency through factory-tested, integrity-verified devices.

Key Supor (PES) Membrane Characteristics

• Supor capsule devices are constructed from materials with documented biocompatibility and low extractable characteristics suitable for pharmaceutical manufacturing processes.
• Supor PES membrane exhibits broad compatibility with aqueous buffers, aliphatic alcohols, and glycols across pH 1-14, supporting diverse pharmaceutical processing applications within a single membrane platform.
• Rated for continuous operation at temperatures up to 40 degrees Celsius, the capsule maintains structural integrity and retention performance across the normal process temperature range.
• Maximum operating pressure of 75 psi provides the differential pressure capacity needed for sustained filtration of viscous solutions and high-flow process streams.
• The Supor membrane platform provides consistent filtration performance across capsule formats from laboratory-scale evaluation devices through production-scale large-volume capsules.

Key Capsule Construction Features

• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

From method development through scale-up to production, your capsule filter choice defines the balance between membrane performance, process integration, and the regulatory documentation trail that supports each filtration event. In response, for biopharmaceutical manufacturing where retention validation and product recovery are equally critical, Supor membrane technology delivers the documented performance and ultra-low binding your process demands. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Non-sterile delivery accommodates applications where sterility is not required, while the all-polypropylene construction provides the option for autoclave sterilization when aseptic processing is specified.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

48 psi

Burst Pressure (psi)

75 psi

Capsule Format

AcroPak 400

Compliance Standards

USP Class VI <88>; Endotoxin < 0.25 EU/mL (LAL)

Construction

Polypropylene

Filling Bell (Yes/ No)

No

Filtration Area

375 cm²

Flow Rate

0.7 L/min

Inlet Connection

1 to 1-1/2 in. sanitary flange

Material

PES

Max Batch Volume

Medium-volume batch processing

Maximum Operating Pressure

75 psi

Maximum Operating Temperature (°C)

40 °C

Membrane Brand

Supor EKV

Outlet Connection

1 to 1-1/2 in. sanitary flange

Pack Count

1

Pore Size (µm)

0.2

Pre-filter Pore Size

0.65

Prefilter (Yes/No)

Yes

Sterility

Nonsterile

Sterilization

Autoclave

Vent (Yes/ No)

Yes

Wettability

Hydrophilic

• Scale-Up Filtration - Consistent Supor membrane performance from laboratory evaluation through pilot and full production batch volumes.
• Biologics Processing - Ultra-low binding PES membrane preserves therapeutic protein concentrations through production-scale processing.
• Buffer Systems - Broad pH compatibility from 1 to 14 supports validated filtration across the full range of pharmaceutical buffer solutions.
• Cell Culture Media - High-throughput filtration of tissue culture media with flow rates optimized for large-volume batch processing.
• Validation Support - Comprehensive manufacturer documentation including extractable profiles and bacterial challenge test data supports integration into regulated processes.
• Process Compatibility - Supor PES membrane exhibits broad compatibility with aqueous buffers, aliphatic alcohols, and glycols across pH 1-14.