AcroPak 800 Capsules w/ Fluorodyne II Membrane - 0.2um, Gamma-Irradiated , 1/Pk SKU: 12471

PVDF Capsule Filters - 12471

For formulations where preservative binding or API adsorption compromises product potency, PVDF capsule filters minimize losses through ultra-low non-specific surface interactions. Engineered for demanding applications, the modified PVDF membrane surface minimizes adsorptive losses of proteins, preservatives, and active compounds, making the capsule format particularly suited to processing sensitive pharmaceutical and biological formulations. For this reason, the outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key PVDF Membrane Characteristics

PVDF membrane capsules combine ultra-low protein binding with broad chemical compatibility, balancing sample recovery with resistance to the pharmaceutical solvents encountered in formulation processing.
PVDF capsule filters generate low extractable levels compatible with parenteral, ophthalmic, and other regulated dosage form applications.
PVDF capsule filters maintain consistent retention and flow performance across the operating pressure and temperature ranges encountered in standard pharmaceutical manufacturing conditions.
PVDF membrane construction within the capsule supports validated bacterial retention testing, with the sterilizing-grade performance documentation required by cGMP manufacturing protocols.
Hydrophilic PVDF membrane surfaces minimize non-specific adsorption of proteins, preservatives, and active pharmaceutical ingredients, protecting formulation potency through the filtration step.

Key Capsule Construction Features

The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.
Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.

As batch volumes and regulatory expectations continue to grow, your capsule filter selection becomes a process design decision that affects sterility assurance, product recovery, and operational cost per liter filtered. With these demands in mind, if your formulation contains preservatives, low-concentration APIs, or binding-sensitive biologics, the ultra-low adsorption characteristics of PVDF membrane construction preserve your product's potency through filtration. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Standard autoclave cycles at 121 degrees Celsius are compatible with the polypropylene housing and membrane assembly, allowing preparation for sterile applications at the point of use.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.