AcroPak 800 Capsules w/ Fluorodyne II Membrane - 0.1um, Gamma-Irradiated , 1/Pk SKU: 12473

PVDF Capsule Filters - 12473

For formulations where preservative binding or API adsorption compromises product potency, PVDF capsule filters minimize losses through ultra-low non-specific surface interactions. Manufactured to exacting specifications, the modified PVDF membrane surface minimizes adsorptive losses of proteins, preservatives, and active compounds, making the capsule format particularly suited to processing sensitive pharmaceutical and biological formulations. The result is a filtration workflow that scales efficiently from method development through production, delivering consistent retention performance across the full range of capsule effective filtration areas.

Key PVDF Membrane Characteristics

• Maximum operating pressure of 75 psi provides the differential pressure capacity needed for sustained filtration of viscous solutions and high-flow process streams.
• The 40 degree Celsius temperature limit ensures reliable capsule performance for ambient and moderately heated filtration applications.
• PVDF membrane capsules combine ultra-low protein binding with broad chemical compatibility, balancing sample recovery with resistance to the pharmaceutical solvents encountered in formulation processing.
• Hydrophilic PVDF membrane surfaces minimize non-specific adsorption of proteins, preservatives, and active pharmaceutical ingredients, protecting formulation potency through the filtration step.
• PVDF capsule filters maintain consistent retention and flow performance across the operating pressure and temperature ranges encountered in standard pharmaceutical manufacturing conditions.

Key Capsule Construction Features

• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. For pharmaceutical manufacturing where every microgram of active ingredient matters, PVDF capsule filters minimize the adsorptive losses that compromise your formulation's labeled concentration. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Supplied non-sterile, the polypropylene housing supports autoclave sterilization at 121 degrees Celsius for 20 minutes when aseptic filtration is required by the application protocol.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

46 psi

Burst Pressure (psi)

75 psi

Capsule Format

AcroPak 800

Compliance Standards

USP Class VI <88>; Endotoxin < 0.25 EU/mL (LAL)

Construction

Polypropylene

Diameter

22.5 cm

Filling Bell (Yes/ No)

No

Filtration Area

800 cm²

Flow Rate

0.6 L/min

Inlet Connection

1/4 to 1/2 in. stepped hose barb

Material

PVDF

Max Batch Volume

Large-volume batch processing

Maximum Operating Pressure

75 psi

Maximum Operating Temperature (°C)

40 °C

Membrane Brand

Fluorodyne II

Outlet Connection

1/4 to 1/2 in. stepped hose barb

Pack Count

1

Pore Size (µm)

0.1

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclave

Vent (Yes/ No)

Yes

Wettability

Hydrophilic

• Diagnostic Reagents - Filtration of sensitive diagnostic solutions where binding-related concentration changes affect assay performance.
• Drug Filtration - Ultra-low binding membrane filtration of pharmaceutical formulations where preservative and API recovery are critical.
• Biological Products - Membrane processing of sera, biological extracts, and therapeutic proteins with minimal non-specific adsorption losses.
• Protein Solutions - Capsule filtration of protein-containing solutions with ultra-low adsorptive losses across the fluid path.
• Formulation Processing - Low-binding capsule filtration for pharmaceutical preparations where maintaining labeled potency is essential.
• Preservative Sensitive - Filtration of formulations containing benzalkonium chloride and other preservatives susceptible to membrane binding.