VacuCap 0.45um, 90mm, Gamma-Irradiated , 10/Pk SKU: 4624

Polyethersulfone (PES) Capsule Filters - 4624

For laboratories preparing culture media, buffers, and reagents at bench scale, VacuCap capsule filters deliver membrane-grade retention without the tubing and pump infrastructure of in-line systems. Supporting this capability, bottle-top capsule construction seats the membrane assembly directly above the collection vessel, creating a sealed vacuum-driven fluid path that eliminates the tubing and fittings required by in-line capsule formats. The outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key Polyethersulfone (PES) Membrane Characteristics

• Without an integrated prefilter, the full effective filtration area is dedicated to final retention, maximizing the available membrane surface for applications with clean or pre-filtered feed solutions.
• PES capsule filters achieve flow rates that support large-batch processing without the mid-run device changes that disrupt sterile workflows and introduce contamination risk.
• The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• Rated for continuous operation at temperatures up to 55 degrees Celsius, the capsule maintains structural integrity and retention performance across the normal process temperature range.

Key Capsule Construction Features

• Modified acrylic housing provides optical clarity for visual monitoring of fluid flow, wetting progress, and air displacement during capsule filtration operations.
• Modified acrylic housing delivers low extractable levels suitable for aqueous biological and pharmaceutical filtration applications where fluid purity is a primary concern.
• Sealed acrylic capsule construction is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device ships.
• Bottle-top vacuum filtration design seats directly on standard laboratory collection vessels, creating a sealed fluid path from feed tubing through the membrane to the receiving container.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. If your laboratory prepares culture media, buffers, or reagents at bench scale, VacuCap bottle-top filtration delivers membrane-grade retention with the vacuum-driven simplicity your daily workflow demands. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Designed for non-sterile filtration applications, the device provides effective particulate removal and clarification performance without the sterilization compatibility required for aseptic processing.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Capsule Format

VacuCap

Compliance Standards

Endotoxin < 0.25 EU/mL (LAL)

Construction

Modified acrylic

Diameter

9 cm

Filling Bell (Yes/ No)

No

Filtration Area

60 cm²

Flow Rate

0.56 L/min at 10 in. Hg

Holdup Volume

4.3 mL

Inlet Connection

Feed tubing port

Material

PES

Max Batch Volume

5 L

Maximum Operating Pressure

25 in. Hg (vacuum)

Maximum Operating Temperature (°C)

55 °C

Membrane Brand

Supor

Outlet Connection

Vacuum port (bottle-top seal)

Pack Count

10

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Not suitable for sterile applications

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Buffer Clarification - Vacuum filtration of laboratory buffers and reagent solutions directly into collection bottles for immediate use.
• Small Batch Media - Preparation of filtered tissue culture media in volumes suited to individual experiments and small-scale cell culture operations.
• Media Preparation - Bench-scale filtration of tissue culture media and biological supplements using vacuum-driven bottle-top convenience.
• Water Polishing - Final filtration of laboratory-grade water into sterile collection vessels for cell culture and sensitive analytical applications.
• Laboratory Convenience - Bench-scale vacuum filtration eliminates the tubing and pump setups required by in-line capsule devices.
• Reagent Processing - Convenient benchtop filtration of aqueous reagents and solutions where pump infrastructure is unavailable or impractical.