VacuCap 0.45um, 60mm, Gamma-Irradiated , 10/Pk SKU: 4634

Polyethersulfone (PES) Capsule Filters - 4634

Gamma-sterilized and ready for immediate use, VacuCap capsule filters provide membrane filtration in a bottle-top format designed for bench-scale laboratory convenience and operational simplicity. Moreover, bottle-top capsule construction seats the membrane assembly directly above the collection vessel, creating a sealed vacuum-driven fluid path that eliminates the tubing and fittings required by in-line capsule formats. Because of this, the outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key Polyethersulfone (PES) Membrane Characteristics

• Capsule holdup volume of 2.2 milliliters represents the fluid retained within the device after filtration, an important factor when calculating yield for high-value pharmaceutical products.
• Single-layer membrane construction provides direct, absolute retention at the rated pore size without the additional flow resistance introduced by upstream prefilter layers.
• The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.
• The non-sterile format provides the same membrane retention and flow performance as sterile variants, with the flexibility for user-controlled sterilization when process requirements dictate.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.

Key Capsule Construction Features

• Acrylic capsule housing is compatible with gamma irradiation sterilization, arriving factory-sterilized and ready for immediate use in aseptic filtration workflows.
• Integrated bottle-top sealing geometry provides a contamination-resistant interface between the capsule and collection vessel during vacuum-assisted filtration operations.
• Modified acrylic housing provides optical clarity for visual monitoring of fluid flow, wetting progress, and air displacement during capsule filtration operations.
• The translucent acrylic housing enables operators to confirm complete membrane wetting and monitor filtrate flow without interrupting the filtration process.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. In these cases, for bench-scale filtration tasks where pump infrastructure and tubing connections add unnecessary complexity, VacuCap devices provide the operational convenience your laboratory routine requires. Secure your research outcomes by partnering with a filtration solution that understands your need for speed, accuracy, and reproducibility.

Sterilization Guidance

Non-sterile delivery and non-autoclavable housing construction position the device for applications where particle removal and sample clarity are the primary objectives rather than sterile effluent production.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Capsule Format

VacuCap

Compliance Standards

Endotoxin < 0.25 EU/mL (LAL)

Construction

Modified acrylic

Diameter

6 cm

Filling Bell (Yes/ No)

No

Filtration Area

30 cm²

Flow Rate

0.28 L/min at 10 in. Hg

Holdup Volume

2.2 mL

Inlet Connection

Feed tubing port

Material

PES

Max Batch Volume

1 L

Maximum Operating Pressure

25 in. Hg (vacuum)

Maximum Operating Temperature (°C)

55 °C

Membrane Brand

Supor

Outlet Connection

Vacuum port (bottle-top seal)

Pack Count

10

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Not suitable for sterile applications

Vent (Yes/ No)

No

Wettability

Hydrophilic

• Media Preparation - Bench-scale filtration of tissue culture media and biological supplements using vacuum-driven bottle-top convenience.
• Reagent Processing - Convenient benchtop filtration of aqueous reagents and solutions where pump infrastructure is unavailable or impractical.
• Small Batch Media - Preparation of filtered tissue culture media in volumes suited to individual experiments and small-scale cell culture operations.
• Water Polishing - Final filtration of laboratory-grade water into sterile collection vessels for cell culture and sensitive analytical applications.
• Buffer Clarification - Vacuum filtration of laboratory buffers and reagent solutions directly into collection bottles for immediate use.
• Laboratory Convenience - Bench-scale vacuum filtration eliminates the tubing and pump setups required by in-line capsule devices.