PES Capsule Filter, 0.45um, 72mm x 115mm, 1/4 in. MNPT, Nonsterile, 1/Pk SKU: SF14921

Polyethersulfone (PES) Capsule Filters - SF14921

PES capsule filters address the growing demand for single-use, validated filtration devices that integrate directly into pharmaceutical and biopharmaceutical fluid transfer systems. Optimized for laboratory use, PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. Altogether, the outcome is simplified regulatory documentation and reduced contamination risk, with each single-use capsule providing a validated, traceable filtration event.

Key Polyethersulfone (PES) Membrane Characteristics

• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• Rated for continuous operation at temperatures up to 80 degrees Celsius, the capsule maintains structural integrity and retention performance across the normal process temperature range.
• PES capsule filters achieve flow rates that support large-batch processing without the mid-run device changes that disrupt sterile workflows and introduce contamination risk.
• Non-sterile capsule configuration supports applications where terminal sterilization is not required or where the user will perform site-specific sterilization by autoclaving.
• The asymmetric pore structure of PES membranes captures contaminants at the upstream surface while maintaining open downstream channels, extending capsule throughput before reaching differential pressure limits.

Key Capsule Construction Features

• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.
• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.

As batch volumes and regulatory expectations continue to grow, your capsule filter selection becomes a process design decision that affects sterility assurance, product recovery, and operational cost per liter filtered. For this application, if your process involves aqueous biologicals, the ultra-low protein binding and broad pH compatibility of PES membrane construction protect your product while sustaining the flow rates your batch schedule requires. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

26.1psi

Compliance Standards

ISO 9001

Connection Type

1/4 in. MNPT

Construction

Polypropylene

Diameter

72mm

Dimensions

72mm x 115mm

Filling Bell (Yes/ No)

No

Filtration Area

1000cm²

Flow Rate

4.5 L/min at 0.1 bar

Holdup Volume

60mL

Inlet Connection

1/4 in. MNPT

Length

115mm

Material

PES

Max Batch Volume

＜50L

Maximum Operating Pressure

75.4psi

Maximum Operating Temperature (°C)

80°C

Outlet Connection

1/4 in. MNPT

Pack Count

1

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclavable at 121°C for 30 mins

Vent (Yes/ No)

Yes

Weight

0.42

Wettability

Hydrophilic

• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.