PES Capsule Filter, 0.45um, 72mm x 100mm, 3/8 in. Hose Barb, Nonsterile, 1/Pk SKU: SF14952

Polyethersulfone (PES) Capsule Filters - SF14952

When processing aqueous biologicals at volumes beyond syringe filter capacity, PES capsule filters provide the throughput and recovery performance that bench-scale devices cannot match. Moreover, PES membrane chemistry delivers broad pH compatibility from 1 to 14, supporting filtration of buffers, media, and cleaning solutions through a single capsule platform without material degradation. The result is a streamlined filtration step that integrates directly into fluid transfer systems, reducing hold times and minimizing the manual handling that compromises sterility assurance.

Key Polyethersulfone (PES) Membrane Characteristics

• The inherently hydrophilic PES membrane wets immediately on contact with aqueous solutions, eliminating alcohol pre-flush steps and reducing both startup time and solvent waste.
• The single membrane configuration is appropriate for pre-clarified feed streams where upstream particulate removal has already reduced the contaminant load to levels within the capsule's dirt-holding capacity.
• PES membrane construction supports integrity testing by forward flow, bubble point, or pressure decay methods, providing the post-use verification required by pharmaceutical quality systems.
• Ultra-low protein binding characteristics of the PES membrane minimize adsorptive losses, preserving the concentration and biological activity of filtered proteins, antibodies, and growth factors.
• Non-sterile capsules support autoclave sterilization where the membrane and housing materials permit, allowing users to prepare devices according to their own validated sterilization protocols.

Key Capsule Construction Features

• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
• Polypropylene housing materials provide documented biocompatibility and low extractable profiles, supporting integration into pharmaceutical and food-processing filtration applications.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.

As single-use filtration continues to replace reusable housings across pharmaceutical and laboratory environments, your capsule filter selection determines both the quality of the filtrate and the efficiency of the workflow. Meeting this challenge, if your process involves aqueous biologicals, the ultra-low protein binding and broad pH compatibility of PES membrane construction protect your product while sustaining the flow rates your batch schedule requires. Elevate the quality of your analytical data today by standardizing on a filtration product built to meet the exact specifications of your applications.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

26.1psi

Compliance Standards

ISO 9001

Connection Type

3/8 in. hose barb

Construction

Polypropylene

Diameter

72mm

Dimensions

72mm x 100mm

Filling Bell (Yes/ No)

No

Filtration Area

500cm²

Flow Rate

2.2 L/min at 0.1 bar

Holdup Volume

25mL

Inlet Connection

3/8 in. Hose Barb

Length

100mm

Material

PES

Max Batch Volume

＜20L

Maximum Operating Pressure

75.4psi

Maximum Operating Temperature (°C)

80°C

Outlet Connection

3/8 in. Hose Barb

Pack Count

1

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclavable at 121°C for 30 mins

Vent (Yes/ No)

Yes

Weight

0.25

Wettability

Hydrophilic

• Biologics Protection - Ultra-low protein binding preserves antibody and growth factor concentrations through the membrane retention step.
• Process Intermediates - In-line capsule filtration of pharmaceutical intermediates with validated retention and low adsorptive losses.
• Buffer Processing - Large-volume filtration of pharmaceutical buffers and process solutions with broad pH compatibility across pH 1-14.
• Reagent Filtration - Removal of particulates and contaminants from laboratory reagents and process solutions before downstream use.
• Water Purification - Membrane-grade filtration of purified water and water-for-injection systems in pharmaceutical manufacturing facilities.
• Serum Processing - Capsule filtration of animal sera and biological supplements for cell culture and diagnostic reagent applications.