Tisch
Hydrophilic PTFE Syringe Filters for LC-MS, 0.22 um, 25mm, Luer-Lok/Luer Slip, 10/Pk SKU: SF02225LCMS

Polytetrafluoroethylene (PTFE) Syringe Filters - SF02225LCMS

Featuring specialized hydrophilic PTFE membrane technology at 0.22μm pore size, engineered specifically for LC-MS applications where extractables-free filtration and absolute bacterial retention are paramount. Surface-modified fluoropolymer chemistry eliminates pre-wetting requirements while delivering ultra-low extractables profile critical for mass spectrometry sensitivity and accuracy. Liquid chromatography mass spectrometry, analytical method development, and trace analysis laboratories demand filtration solutions that prevent background interference while maintaining sterile sample integrity. Construction specifications include 25mm diameter platform with 4.08cm² filtration area optimized for 50ml sample processing, polypropylene housing rated to 60°C operation, and 100μL holdup volume with 18ml flow rate characteristics supporting efficient medium-volume analytical workflows requiring highest purity standards.

Key PTFE Membrane Characteristics

• Absolute 0.22μm Sterile Filtration - Delivers complete bacterial removal with 43.51psi bubble point validation for critical analytical applications
• Ultra-Low Extractables Profile - Minimizes background interference in LC-MS analysis, ensuring accurate trace detection and quantification
• Hydrophilic Surface Engineering - Modified fluoropolymer eliminates pre-wetting protocols, enabling immediate aqueous sample processing
• Broad Solvent Compatibility - Withstands aggressive mobile phases and extraction solvents throughout analytical method development
• Minimal Protein Adsorption - Low-binding surface maintains concentration of analytes and biologics during sample preparation workflows

Key Construction Characteristics

• 100μL Holdup Volume - Preserves samples through optimized dead volume design, enabling maximum recovery of valuable analytical specimens
• 25mm LC-MS Optimized Platform - 4.08cm² filtration area provides efficient processing for medium-volume samples up to 50ml capacity
• Universal Dual Luer Interface - Luer-Lok/Luer Slip compatibility ensures secure connection with all standard laboratory syringe systems
• Extractables-Minimized Construction - Clean polypropylene housing minimizes contamination sources for trace analytical applications

Designed for your most demanding LC-MS applications, this hydrophilic PTFE system delivers a safety margin through 87psi maximum operating pressure while providing ultra-low extractables assurance. Your analytical laboratory achieves accurate trace detection through minimized background interference and maximum sample recovery through optimized holdup design, while the robust construction ensures consistent sterile filtration performance across sensitive mass spectrometry workflows requiring the highest purity and analytical accuracy standards.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

43.51psi

Connection Type

Luer-Lok/ Luer Slip

Construction

PP

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

18ml

Holdup Volume

100μL

Material

Polytetrafluoroethylene (PTFE)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

80-140μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

No

Sterility

NonSterile

Sterilization

Autoclave 121°C for 30min/ Gamma 25kGy

Volume Throughput (ml)

50ml

Wetability

Hydrophilic

• LC-MS Sample Preparation - Sterilizes analytical samples while preventing extractables interference in mass spectrometry detection
• Pharmaceutical Method Development - Filters drug formulations and impurity studies requiring ultra-clean filtration for trace analysis
• Metabolomics Research - Processes biological samples for mass spectrometry without introducing contaminating background peaks
• Environmental Trace Analysis - Sterilizes water and soil extracts for pesticide and contaminant detection at parts-per-billion levels
• Proteomics Sample Processing - Filters protein digests and peptide solutions for LC-MS/MS analysis with minimal sample loss
• Quality Control Testing - Prepares pharmaceutical and biotechnology samples for trace impurity analysis and release testing