Tisch
Hydrophilic PTFE Syringe Filters for LC-MS, 0.22 um, 25mm, Luer-Lok/Luer Slip, 10/Pk SKU: SF02225LCMS

Polytetrafluoroethylene (PTFE) Syringe Filters - SF02225LCMS

When you're preparing samples for LC-MS analysis, background interference from extractables can ruin your results. These 0.22µm hydrophilic PTFE filters minimize contamination with an ultra-low extractables profile that won't introduce background peaks in your mass spectra. The hydrophilic surface processes aqueous samples immediately without alcohol pre-wetting, and the 0.22µm pore size removes bacteria when sterile filtration is required. With 100µL holdup volume and 4.08cm² filtration area, you can process up to 50ml samples while maximizing recovery of precious analytical specimens.

Key PTFE Membrane Characteristics

• 0.22µm sterile-grade filtration removes bacteria with 43.51psi bubble point specification for analytical applications
• Ultra-low extractables profile minimizes background interference in LC-MS analysis for accurate trace detection
• Hydrophilic surface modification eliminates pre-wetting requirements for immediate aqueous sample processing
• Broad chemical compatibility withstands aggressive mobile phases and extraction solvents across analytical methods
• Low protein binding maintains analyte concentrations during sample preparation for biological analyses

Key Construction Characteristics

• 100µL holdup volume maximizes recovery of valuable analytical samples and expensive reagents
• 25mm diameter with 4.08cm² filtration area processes medium-volume samples up to 50ml efficiently
• Luer-Lok/Luer Slip dual connection accommodates all standard laboratory syringe configurations
• Low-extractables polypropylene housing minimizes contamination sources for trace analytical applications

You can autoclave these filters at 121°C for 30 minutes when your protocols require pre-sterilization, or use them directly for clarification and bacterial removal from analytical samples. The 87psi burst pressure handles typical analytical workflows, and the ultra-low extractables profile means you won't see background peaks interfering with your target analytes. Process samples at temperatures up to 60°C, and the 43.51psi bubble point confirms consistent pore structure for reproducible filtration across your analytical runs.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

43.51psi

Connection Type

Luer-Lok/ Luer Slip

Construction

PP

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

18ml

Holdup Volume

100μL

Material

Polytetrafluoroethylene (PTFE)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

80-140μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

No

Sterility

NonSterile

Sterilization

Autoclave 121°C for 30min/ Gamma 25kGy

Volume Throughput (ml)

50ml

Weight

0.08

Wetability

Hydrophilic

• LC-MS Sample Preparation - Removes particles and bacteria from analytical samples while preventing extractables interference in mass spectrometry detection
• Pharmaceutical Method Development - Filters drug formulations and impurity studies requiring ultra-clean filtration for trace analysis without background peaks
• Metabolomics Research - Processes biological samples for mass spectrometry analysis without introducing contaminating extractables or background interference
• Environmental Trace Analysis - Clarifies water and soil extracts for pesticide and contaminant detection at parts-per-billion sensitivity levels
• Proteomics Sample Processing - Filters protein digests and peptide solutions for LC-MS/MS analysis with minimal sample loss and low extractables
• Quality Control Testing - Prepares pharmaceutical and biotechnology samples for trace impurity analysis and regulatory release testing requirements