Tisch
Hydrophilic PTFE Syringe Filters for LC-MS, 0.45um, 25mm, Luer-Lok/Luer Slip, 10/Pk SKU: SF04525LCMS

Polytetrafluoroethylene (PTFE) Syringe Filters - SF04525LCMS

Background interference from extractables and particulate contamination creates critical challenges in LC-MS applications where trace detection sensitivity cannot be compromised by filtration artifacts. Traditional clarification filters introduce contaminating compounds that create phantom peaks and suppress ionization efficiency, reducing analytical accuracy and method reliability. Specialized hydrophilic PTFE membrane technology at 0.45μm eliminates these obstacles through ultra-low extractables design combined with efficient particulate removal optimized specifically for mass spectrometry workflows. Technical specifications include 21.75psi bubble point validation ensuring consistent 0.45μm clarification, 25mm platform with 4.08cm² filtration area, and 100μL holdup volume delivering exceptional 35ml flow rates with 50ml throughput capacity for demanding LC-MS sample preparation requiring minimal background interference and maximum analytical sensitivity.

Key PTFE Membrane Characteristics

• LC-MS Optimized 0.45μm Clarification - Removes interfering particles while maintaining ultra-low extractables profile for clean mass spectrometry analysis
• Hydrophilic Surface Treatment - Modified fluoropolymer chemistry eliminates pre-wetting procedures, enabling immediate aqueous sample processing
• Minimal Extractables Design - Ultra-clean membrane construction prevents background interference in trace analytical applications
• Broad Solvent Compatibility - Resists aggressive mobile phases and extraction solvents throughout chromatographic method development
• Low Protein Binding Surface - Maintains concentration of analytes and biologics, preventing losses during sample preparation workflows

Key Construction Characteristics

• 100μL Holdup Volume - Minimizes loss through optimized dead space design, balancing sample recovery with processing efficiency
• 25mm LC-MS Platform - 4.08cm² effective area enables rapid processing of medium-volume samples with 50ml capacity
• Extractables-Minimized Housing - Clean polypropylene construction reduces contamination sources critical for trace analytical applications
• Universal Dual Luer Connection - Luer-Lok/Luer Slip interface ensures secure integration with all standard laboratory syringe systems

Engineered for your most sensitive LC-MS applications, this hydrophilic PTFE system delivers reliable performance through 87psi operational ratings while providing ultra-low extractables assurance. Your analytical laboratory achieves accurate trace detection through minimized background interference and efficient sample processing through 35ml flow rates, while the clean construction ensures consistent clarification performance across demanding mass spectrometry workflows requiring the highest sensitivity and analytical precision standards.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

21.75psi

Connection Type

Luer-Lok/ Luer Slip

Construction

PP

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

35ml

Holdup Volume

100μL

Material

Polytetrafluoroethylene (PTFE)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

80-140μm

Pack Count

100

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Prefilter Material

/

Sterility

NonSterile

Sterilization

Autoclave 121°C for 30min/ Gamma 25kGy

Volume Throughput (ml)

50ml

Wetability

Hydrophilic

• LC-MS Sample Clarification - Removes particulates from analytical samples without introducing extractables interference in mass detection
• Pharmaceutical Impurity Analysis - Clarifies drug formulations for trace impurity detection requiring ultra-clean filtration protocols
• Metabolomics Sample Preparation - Processes biological samples for mass spectrometry, preventing contaminating background peak formation
• Environmental Trace Analysis - Clarifies water and soil extracts for pesticide detection at parts-per-billion sensitivity levels
• Proteomics Research - Filters protein digests and peptide solutions for LC-MS/MS analysis with minimal extractables interference
• Quality Control Testing - Prepares pharmaceutical samples for trace analysis and release testing with maximum analytical accuracy