Tisch
Hydrophilic PTFE Syringe Filters for LC-MS, 0.45um, 25mm, Luer-Lok/Luer Slip, 10/Pk SKU: SF04525LCMS

Polytetrafluoroethylene (PTFE) Syringe Filters - SF04525LCMS

When you're preparing samples for LC-MS analysis, background interference from extractables can ruin your results. These 0.45µm hydrophilic PTFE filters minimize contamination with an ultra-low extractables profile that won't introduce background peaks in your mass spectra. The hydrophilic surface processes aqueous samples immediately without pre-wetting, and the 0.45µm pore size removes particles while preserving your dissolved analytes. With 100µL holdup volume and 4.08cm² filtration area, you can process up to 50ml samples while maximizing recovery of precious analytical specimens.

Key PTFE Membrane Characteristics

• 0.45µm pore size removes particles while maintaining ultra-low extractables profile for clean LC-MS analysis
• Hydrophilic surface modification eliminates pre-wetting requirements for immediate aqueous sample processing
• Ultra-low extractables design prevents background interference in trace analytical applications
• Broad chemical compatibility withstands aggressive mobile phases and extraction solvents
• Low protein binding maintains analyte concentrations during sample preparation

Key Construction Characteristics

• 100µL holdup volume maximizes recovery of valuable analytical samples
• 25mm diameter with 4.08cm² filtration area processes medium-volume samples up to 50ml efficiently
• Low-extractables polypropylene housing minimizes contamination sources for trace analytical applications
• Luer-Lok/Luer Slip dual connection accommodates all standard laboratory syringe configurations

You can autoclave these filters at 121°C for 30 minutes when your protocols require pre-sterilization before use. The ultra-low extractables profile means you won't see background peaks interfering with your target analytes in mass spectra. Process samples at typical laboratory temperatures, and the 87psi burst pressure handles standard analytical workflows. The 21.75psi bubble point confirms consistent 0.45µm pore structure for reproducible particle removal across your LC-MS sample preparation runs.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

21.75psi

Connection Type

Luer-Lok/ Luer Slip

Construction

PP

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

35ml

Holdup Volume

100μL

Material

Polytetrafluoroethylene (PTFE)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

80-140μm

Pack Count

100

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Prefilter Material

/

Sterility

NonSterile

Sterilization

Autoclave 121°C for 30min/ Gamma 25kGy

Volume Throughput (ml)

50ml

Weight

0.08

Wetability

Hydrophilic

• LC-MS Sample Clarification - Removes particulates from analytical samples without introducing extractables interference in mass detection
• Pharmaceutical Impurity Analysis - Clarifies drug formulations for trace impurity detection requiring ultra-clean filtration protocols
• Metabolomics Sample Preparation - Processes biological samples for mass spectrometry, preventing contaminating background peak formation
• Environmental Trace Analysis - Clarifies water and soil extracts for pesticide detection at parts-per-billion sensitivity levels
• Proteomics Research - Filters protein digests and peptide solutions for LC-MS/MS analysis with minimal extractables interference
• Quality Control Testing - Prepares pharmaceutical samples for trace analysis and release testing with maximum analytical accuracy