PVDF Capsule Filter, 0.22 um, 72mm x 115mm, 1/4 in. MNPT, Nonsterile, 1/Pk SKU: SF15007

PVDF Capsule Filters - SF15007

When formulation integrity depends on minimizing membrane interactions, PVDF capsule filters deliver the adsorption performance that protects active ingredient concentrations through filtration. Optimized for laboratory use, hydrophilic PVDF membrane within the capsule housing combines ultra-low protein binding with validated bacterial retention, preserving active pharmaceutical ingredients while removing microorganisms from production fluid streams. To this end, the result is a filtration workflow that scales efficiently from method development through production, delivering consistent retention performance across the full range of capsule effective filtration areas.

Key PVDF Membrane Characteristics

• PVDF capsule filters generate low extractable levels compatible with parenteral, ophthalmic, and other regulated dosage form applications.
• Single-membrane construction simplifies integrity test interpretation, as the bubble point and diffusion flow values correspond directly to the rated retention membrane without prefilter interference.
• Internal holdup volume of 60 milliliters minimizes sample loss during capsule filtration, a critical consideration when processing expensive biologics or limited-volume preparations.
• Maximum operating pressure of 75.4 psi provides the differential pressure capacity needed for sustained filtration of viscous solutions and high-flow process streams.
• The low-binding PVDF membrane surface reduces the filter-related losses that become significant when processing low-concentration or high-value pharmaceutical formulations at production scale.

Key Capsule Construction Features

• The sealed polypropylene housing is individually integrity-tested during manufacturing, verifying membrane installation and housing seal quality before the device leaves the production facility.
• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.

From method development through scale-up to production, your capsule filter choice defines the balance between membrane performance, process integration, and the regulatory documentation trail that supports each filtration event. If your formulation contains preservatives, low-concentration APIs, or binding-sensitive biologics, the ultra-low adsorption characteristics of PVDF membrane construction preserve your product's potency through filtration. Secure your research outcomes by partnering with a filtration solution that understands your need for speed, accuracy, and reproducibility.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

14.5psi

Compliance Standards

ISO 9001

Connection Type

1/4 in. MNPT

Construction

Polypropylene

Diameter

72mm

Dimensions

72mm x 115mm

Filling Bell (Yes/ No)

No

Filtration Area

1000cm²

Flow Rate

0.6 L/min at 0.1 bar

Holdup Volume

60mL

Inlet Connection

1/4 in. MNPT

Length

115mm

Material

PVDF

Max Batch Volume

＜50L

Maximum Operating Pressure

75.4psi

Maximum Operating Temperature (°C)

80°C

Outlet Connection

1/4 in. MNPT

Pack Count

1

Pore Size (µm)

0.22

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclavable at 121°C for 30 mins

Vent (Yes/ No)

Yes

Weight

0.39

Wettability

Hydrophilic

• Preservative Sensitive - Filtration of formulations containing benzalkonium chloride and other preservatives susceptible to membrane binding.
• Formulation Processing - Low-binding capsule filtration for pharmaceutical preparations where maintaining labeled potency is essential.
• Biological Products - Membrane processing of sera, biological extracts, and therapeutic proteins with minimal non-specific adsorption losses.
• Drug Filtration - Ultra-low binding membrane filtration of pharmaceutical formulations where preservative and API recovery are critical.
• Diagnostic Reagents - Filtration of sensitive diagnostic solutions where binding-related concentration changes affect assay performance.
• Protein Solutions - Capsule filtration of protein-containing solutions with ultra-low adsorptive losses across the fluid path.