PVDF Capsule Filter, 0.45um, 72mm x 115mm, 1/4 in. MNPT, Nonsterile, 1/Pk SKU: SF15008

PVDF Capsule Filters - SF15008

PVDF capsule filters deliver ultra-low protein binding alongside broad chemical compatibility, making them a preferred choice for pharmaceutical and biopharmaceutical filtration at scale. Designed for laboratory performance, hydrophilic PVDF membrane within the capsule housing combines ultra-low protein binding with validated bacterial retention, preserving active pharmaceutical ingredients while removing microorganisms from production fluid streams. The result is a streamlined filtration step that integrates directly into fluid transfer systems, reducing hold times and minimizing the manual handling that compromises sterility assurance.

Key PVDF Membrane Characteristics

• PVDF capsule filters generate low extractable levels compatible with parenteral, ophthalmic, and other regulated dosage form applications.
• The low-binding PVDF membrane surface reduces the filter-related losses that become significant when processing low-concentration or high-value pharmaceutical formulations at production scale.
• The 80 degree Celsius temperature limit ensures reliable capsule performance for ambient and moderately heated filtration applications.
• PVDF membrane construction within the capsule supports validated bacterial retention testing, with the sterilizing-grade performance documentation required by cGMP manufacturing protocols.
• Hydrophilic PVDF membrane surfaces minimize non-specific adsorption of proteins, preservatives, and active pharmaceutical ingredients, protecting formulation potency through the filtration step.

Key Capsule Construction Features

• Single-use polypropylene capsule construction eliminates cleaning validation requirements, reducing the regulatory burden and turnaround time associated with reusable stainless steel filter housings.
• Thermally fused polypropylene construction eliminates adhesives, binders, and O-rings from the fluid path, reducing extractable contamination and simplifying material qualification.
• Polypropylene capsule housing supports autoclave sterilization at 121 degrees Celsius and withstands gamma irradiation exposure, accommodating both user-sterilized and factory-sterilized device configurations.
• Polypropylene capsule housing provides broad chemical compatibility from pH 1 to 14, resisting the acids, bases, and process chemicals that degrade alternative housing materials.

Your laboratory's filtration throughput depends not only on membrane retention characteristics but on the practical factors of device connection, priming, and changeover that capsule filters are specifically engineered to optimize. To meet this need, when your filtration step must protect both product purity and product potency, PVDF membrane chemistry delivers the low-binding performance your sensitive formulations require. Make the decision for consistency and reliability, ensuring that your laboratory maintains its reputation for high-quality, error-free output.

Sterilization Guidance

Polypropylene construction throughout the device permits autoclave sterilization at standard conditions, enabling end-user preparation for sterile filtration applications as needed.

For more information about chemical compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

8.7psi

Compliance Standards

ISO 9001

Connection Type

1/4 in. MNPT

Construction

Polypropylene

Diameter

72mm

Dimensions

72mm x 115mm

Filling Bell (Yes/ No)

No

Filtration Area

1000cm²

Flow Rate

3.2 L/min at 0.1 bar

Holdup Volume

60mL

Inlet Connection

1/4 in. MNPT

Length

115mm

Material

PVDF

Max Batch Volume

＜50L

Maximum Operating Pressure

75.4psi

Maximum Operating Temperature (°C)

80°C

Outlet Connection

1/4 in. MNPT

Pack Count

1

Pore Size (µm)

0.45

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclavable at 121°C for 30 mins

Vent (Yes/ No)

Yes

Weight

0.39

Wettability

Hydrophilic

• Formulation Processing - Low-binding capsule filtration for pharmaceutical preparations where maintaining labeled potency is essential.
• Preservative Sensitive - Filtration of formulations containing benzalkonium chloride and other preservatives susceptible to membrane binding.
• Diagnostic Reagents - Filtration of sensitive diagnostic solutions where binding-related concentration changes affect assay performance.
• Drug Filtration - Ultra-low binding membrane filtration of pharmaceutical formulations where preservative and API recovery are critical.
• Biological Products - Membrane processing of sera, biological extracts, and therapeutic proteins with minimal non-specific adsorption losses.
• Protein Solutions - Capsule filtration of protein-containing solutions with ultra-low adsorptive losses across the fluid path.