Tisch
Hydrophilic PVDF Syringe Filters, 0.22 um, 25mm, Luer-Lok/Luer Slip, Nonsterile, 100/Pk SKU: SF17390

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF17390

Featuring hydrophilic polyvinylidene fluoride membrane technology with 0.22 µm pore size and naturally wettable surface chemistry, these 25mm diameter filters deliver sterile-grade bacterial retention for aqueous biological samples requiring microbial elimination without pre-wetting steps across pharmaceutical manufacturing and biotechnology research workflows. This membrane enables immediate processing of aqueous samples through surface chemistry that eliminates alcohol preparation while maintaining low protein binding characteristics essential for therapeutic protein sterilization. Meanwhile, the design with 2.98 cm² filtration area and 100 µL holdup volume maximizes recovery of valuable pharmaceutical formulations and biological materials for quality control and manufacturing applications processing volumes between 10-100 ml.

Key Hydrophilic PVDF Membrane Characteristics

• Naturally wettable surface eliminates alcohol pre-wetting requirements for aqueous processing, enabling immediate filtration of biological samples without preparatory solvent steps
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, including Brevundimonas diminuta, ensuring microbial control for pharmaceutical manufacturing applications
• Low protein binding affinity maintains concentration of therapeutic proteins and biomolecules during sterilization, minimizing product loss in biopharmaceutical processing
• Chemical compatibility resists degradation from biological buffers and mild acids while maintaining stable operation across pharmaceutical formulation workflows
• Autoclave compatibility at 121°C with gamma sterilization capability provides contamination control options for aseptic pharmaceutical and biotechnology laboratory applications

Key Construction Characteristics

• 100 µL holdup volume optimizes yield by reducing sample retention within the housing, preserving valuable pharmaceutical formulations and biological materials
• Polypropylene housing provides structural integrity to 87 psi maximum operating pressure with thermal stability to 60°C, ensuring reliable performance across laboratory conditions
• Dual Luer-Lok and Luer-Slip connections accommodate standard laboratory syringes without adapters, streamlining aseptic transfer procedures in manufacturing environments
• Single-layer membrane design without a prefilter provides direct sterile filtration for pre-clarified aqueous samples, reducing holdup volume and maximizing biomolecule recovery

Pharmaceutical and biotechnology laboratories processing medium-volume aqueous samples require sterilization technology that combines bacterial retention with immediate wettability and minimal protein loss. Hydrophilic PVDF syringe filters deliver 0.22 µm sterile-grade performance through naturally wettable membrane chemistry and low-holdup design. Designed for your most demanding pharmaceutical workflows, this membrane technology provides operational excellence through immediate aqueous sample processing, validated microbial retention, and low protein binding for biopharmaceutical manufacturing, cell culture sterilization, and quality control applications requiring both efficient processing and bacterial elimination capabilities.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

43.51psi

Connection Type

Luer-Lok/ Luer Slip

Diameter

25mm

Filtration Area

2.98cm²

Flow Rate

20ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

No

Sterility

Nonsterile

Sterilization

Autoclave at 121°C for 30min/ gamma 25kGy

Volume Throughput (ml)

50ml

Wetability

Hydrophilic

• Cell Culture Media Sterilization - Removes bacteria from aqueous culture media and biological supplements for mammalian cell bioprocessing applications
• Biological Buffer Sterilization - Sterilizes phosphate buffers and saline solutions for pharmaceutical manufacturing and laboratory research requiring aseptic conditions
• Therapeutic Protein Filtration - Filters aqueous protein solutions while maintaining biological activity and concentration in biopharmaceutical processing
• Vaccine Sample Processing - Sterilizes aqueous pharmaceutical formulations and biological samples for quality control testing in development laboratories
• Water Quality Testing - Provides sterile aqueous samples for microbiological analysis and environmental monitoring in regulatory compliance programs
• Tissue Culture Supplement Filtration - Sterilizes growth factors and serum additives for cell culture applications requiring contamination-free processing