Tisch
Hydrophilic PVDF Syringe Filters, 0.22 um, 33mm, Luer-Lok/Luer Slip, Nonsterile, 100/Pk SKU: SF17391

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF17391

Precision 0.22 µm hydrophilic polyvinylidene fluoride membrane technology with integrated glass fiber prefilter delivers sterile-grade filtration for high-volume aqueous biological samples requiring bacterial retention, rapid flow characteristics, and low protein binding across pharmaceutical manufacturing and biotechnology research workflows. This configuration combines naturally wettable surface chemistry that eliminates pre-treatment steps with 4.6 cm² filtration area and 33mm diameter design, enabling efficient sterilization of volumes exceeding 100 ml. Meanwhile, the dual-layer construction with 100 µL holdup volume preserves samples by reducing retention within the housing while maintaining compatibility with aqueous buffers, culture media, and biological solutions demanding both microbial control and biomolecule preservation.

Key Hydrophilic PVDF Membrane Characteristics

• Naturally wettable hydrophilic surface eliminates alcohol pre-wetting requirements, enabling immediate processing of aqueous biological samples without preparatory solvent steps
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, including Brevundimonas diminuta, ensuring microbial control for aseptic processing applications
• Low protein binding characteristics maintain the concentration of therapeutic proteins and biomolecules during sterilization, minimizing product loss in biopharmaceutical manufacturing processes
• Broad chemical compatibility resists degradation from mild acids, bases, and biological buffers while maintaining stable operation across pharmaceutical formulation workflows
• Rapid flow characteristics with a 24.5ml/ min flow rate reduce processing time for high-volume sterile filtration in cell culture and buffer preparation applications

Key Construction Characteristics

• 100 µL holdup volume optimizes yield by minimizing sample retention within the filter housing, preserving valuable biological materials and pharmaceutical formulations
• Polypropylene housing construction provides reliable performance to 87 psi maximum operating pressure with thermal stability to 60°C for diverse laboratory conditions
• Dual Luer-Lok and Luer-Slip connections integrate seamlessly with standard laboratory syringes without adapters, streamlining aseptic transfer procedures in manufacturing environments
• Glass fiber prefilter captures coarse particulates and cellular debris upstream of the sterilizing membrane, extending filter lifetime in high-particulate biological samples

Biopharmaceutical and cell culture laboratories processing high-volume aqueous samples require sterilization technology that combines bacterial retention with rapid throughput and minimal protein loss. Hydrophilic PVDF syringe filters deliver 0.22 µm sterile-grade performance through naturally wettable membrane chemistry and integrated prefilter protection. Built to support your critical sterilization workflows, this filtration solution provides performance reliability through proven microbial retention, rapid flow characteristics, and low protein binding for pharmaceutical manufacturing, bioprocessing, and quality control applications demanding both efficient processing and bacterial elimination capabilities.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

43.51psi

Connection Type

Luer-Lok/ Luer Slip

Diameter

33mm

Filtration Area

4.6cm²

Flow Rate

24.5ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

Yes

Prefilter Material

GF

Sterility

Nonsterile

Sterilization

Autoclave at 121°C for 30min/ gamma 25kGy

Volume Throughput (ml)

110ml

Wetability

Hydrophilic

• Cell Culture Media Sterilization - Removes bacteria from aqueous culture media and supplements for mammalian cell bioprocessing and research applications
• Biological Buffer Preparation - Sterilizes phosphate buffers and saline solutions for pharmaceutical manufacturing and laboratory research requiring aseptic conditions
• Vaccine and Biologic Sterilization - Filters aqueous pharmaceutical formulations and parenteral solutions for small-batch production and development applications
• Protein Solution Processing - Sterilizes enzyme solutions and therapeutic protein formulations while maintaining biological activity and concentration
• Water Quality Testing - Provides sterile aqueous samples for microbiological analysis and environmental monitoring in regulatory compliance programs
• Tissue Culture Supplement Filtration - Sterilizes growth factors and serum additives for cell culture applications requiring contamination-free processing