Tisch
Hydrophilic PVDF Syringe Filters, 0.22 um, 33mm, Luer-Lok/Luer Slip, Nonsterile, 100/Pk SKU: SF17391

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF17391

Precision 0.22 µm hydrophilic polyvinylidene fluoride membrane technology features an integrated glass fiber prefilter. It delivers sterile-grade filtration for high-volume aqueous biological samples. The design supports bacterial retention and rapid flow characteristics. Pharmaceutical manufacturing workflows benefit from low protein binding. The configuration combines naturally wettable surface chemistry with a 4.6 cm² filtration area. Users can eliminate pre-treatment steps. Efficient sterilization of volumes exceeding 100 ml supports high-throughput biotechnology workflows. A dual-layer construction with 100 µL holdup volume preserves samples. The housing maintains compatibility with aqueous buffers and biological solutions demanding microbial control.

Key Hydrophilic PVDF Membrane Characteristics

• Naturally wettable hydrophilic surface eliminates alcohol pre-wetting requirements, enabling immediate processing of aqueous biological samples without preparatory solvent steps
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, including Brevundimonas diminuta, ensuring microbial control
• Low protein binding characteristics maintain the concentration of therapeutic proteins and biomolecules during sterilization, minimizing product loss
• Broad chemical compatibility resists degradation from mild acids, bases, and biological buffers while maintaining stable operation across pharmaceutical formulation workflows
• Rapid flow characteristics with a 24.5 ml/min flow rate reduce processing time for high-volume sterile filtration in cell culture and buffer preparation applications

Key Construction Characteristics

• 100 µL holdup volume optimizes yield by minimizing sample retention within the filter housing, preserving valuable biological materials
• Polypropylene housing construction provides reliable performance to 87 psi maximum operating pressure with thermal stability to 60°C for diverse laboratory conditions
• Dual Luer-Lok and Luer-Slip connections integrate seamlessly with standard laboratory syringes without adapters, streamlining aseptic transfer procedures
• Glass fiber prefilter captures coarse particulates and cellular debris upstream of the sterilizing membrane, extending filter lifetime in high-particulate biological samples

Biopharmaceutical laboratories processing high-volume aqueous samples require specific sterilization technology. It must combine bacterial retention with rapid throughput. Hydrophilic PVDF membranes deliver minimal protein loss alongside high-flow performance. Hydrophilic PVDF syringe filters deliver 0.22 µm sterile-grade performance. Naturally wettable membrane chemistry simplifies workflows. Integrated prefilter protection extends filter life. Built to support critical sterilization workflows, the solution provides reliability. Proven microbial retention and low protein binding support manufacturing applications.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

43.51psi

Connection Type

Luer-Lok/ Luer Slip

Diameter

33mm

Filtration Area

4.6cm²

Flow Rate

24.5ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

Yes

Prefilter Material

GF

Sterility

Nonsterile

Sterilization

Autoclave at 121°C for 30min/ gamma 25kGy

Volume Throughput (ml)

110ml

Weight

0.96

Wetability

Hydrophilic

• Cell Culture Media Sterilization - Removes bacteria from culture media and supplements for mammalian cell bioprocessing and research applications
• Biological Buffer Preparation - Sterilizes phosphate buffers and saline solutions for pharmaceutical manufacturing and laboratory research
• Vaccine and Biologic Sterilization - Filters pharmaceutical formulations and parenteral solutions for small-batch production applications
• Protein Solution Processing - Sterilizes enzyme solutions and protein formulations while maintaining biological activity and concentration
• Water Quality Testing - Provides sterile aqueous samples for microbiological analysis and environmental monitoring in regulatory compliance programs
• Tissue Culture Supplement Filtration - Sterilizes growth factors and serum additives for cell culture, requiring contamination-free processing