Tisch
PVDF Syringe Filters, 0.22 um, 25mm, Luer-Lok/Luer Slip, Nonsterile, 100/Pk SKU: SF14456

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF14456

Precision 0.22 µm polyvinylidene fluoride membrane technology delivers sterile-grade filtration for pharmaceutical and chemical applications. The 25mm diameter design combines a 4.08 cm² filtration area with a 100 µL holdup volume. Laboratories can efficiently process sample volumes ranging from 10 to 100 ml. Hydrophobic membrane chemistry withstands aggressive chemical environments while maintaining structural integrity. Such features remain essential for solvent sterilization and workflows demanding microbial control in non-aqueous samples.

Key PVDF Membrane Characteristics

• Hydrophobic surface requires alcohol or solvent pre-wetting before aqueous sample processing, making the membrane ideal for organic mobile phase sterilization
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, removing microorganisms including Brevundimonas diminuta
• Exceptional chemical resistance ensures stable operation across strong acids, bases, alcohols, and chlorinated solvents for diverse pharmaceutical applications
• Naturally hydrophobic surface enables air and gas venting applications, efficiently displacing air from liquid handling systems where hydrophilic membranes would block gas passage
• Thermal stability up to 60°C with autoclave compatibility at 121°C enables filter sterilization for contamination-free processing

Key Construction Characteristics

• 100 µL holdup volume preserves samples by reducing retention within the housing, maximizing recovery of valuable pharmaceutical compounds and analytical standards
• Polypropylene housing construction provides reliable performance to 87 psi maximum operating pressure, delivering operational confidence for pressurized sterilization systems
• Dual Luer-Lok and Luer-Slip connections integrate seamlessly with standard laboratory syringes without requiring adapters, streamlining aseptic transfer procedures
• Integrated polypropylene prefilter captures coarse particulates upstream of the sterilizing membrane, extending filter lifetime in high-particulate sample applications

Laboratories processing medium-volume organic samples require sterilization technology that combines bacterial retention with chemical resistance. PVDF syringe filters deliver 0.22 µm sterile-grade performance through validated membrane technology and integrated prefilter protection. The SF14456 provides performance reliability through proven microbial retention and broad solvent compatibility. Users achieve efficient sample processing for pharmaceutical manufacturing, quality control testing, and demanding research applications.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

14.5psi

Connection Type

Luer-Lok/Luer Slip

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

20ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

Yes

Prefilter Material

PP

Sterility

Nonsterile

Sterilization

Autoclave at 121°C for 30min/ gamma 25kGy

Volume Throughput (ml)

50ml

Weight

0.52

Wetability

Hydrophobic

• Sterile Buffer Preparation - Removes bacteria from aqueous buffer solutions and cell culture media for aseptic processing in biopharmaceutical labs
• HPLC Mobile Phase Sterilization - Provides sterile organic and aqueous mobile phases for liquid chromatography in pharmaceutical quality control
• Pharmaceutical Sterilization - Sterilizes drug solutions and parenteral formulations for small-batch production and research development applications
• Microbiological Sample Preparation - Prepares sterile analytical samples for microbial limit testing and bioburden analysis in regulatory programs
• Tissue Culture Media Filtration - Sterilizes small-volume cell culture supplements and growth factors for mammalian cell research and bioprocessing
• Analytical Standard Sterilization - Removes microbial contamination from reference standards and calibration solutions for validated methods