Tisch
PVDF Syringe Filters, 0.22 um, 25mm, Luer-Lok/Luer Slip, Sterile, 100/Pk SKU: SF14462

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF14462

Precision 0.22 µm polyvinylidene fluoride membrane technology delivers validated bacterial retention for pharmaceutical manufacturing applications. It supports aseptic processing of organic solvents and aggressive chemical formulations across drug development workflows. The 25mm diameter configuration combines 4.08 cm² filtration area with 100 µL holdup volume. Hydrophobic surface chemistry enables reliable sterilization of 10-100 ml sample volumes. The integrated polypropylene prefilter extends operational life by capturing coarse particulates upstream.

Key PVDF Membrane Characteristics

• Hydrophobic surface requires pre-wetting with alcohols or compatible organic solvents before aqueous processing, making this membrane ideal for sterile organic pharmaceutical formulations
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, including Brevundimonas diminuta, ensuring microbial elimination for aseptic pharmaceutical manufacturing
• Exceptional chemical resistance withstands aggressive organic solvents, including chlorinated compounds, alcohols, ketones, and aromatic hydrocarbons across pharmaceutical development workflows
• Naturally hydrophobic surface enables air and gas venting applications, efficiently displacing air from liquid handling systems where hydrophilic membranes would block gas passage
• Sterile packaging eliminates contamination risks for aseptic transfer procedures, supporting GMP compliance requirements in pharmaceutical production environments

Key Construction Characteristics

• 100 µL holdup volume preserves samples by reducing retention within the housing, maximizing recovery of valuable pharmaceutical compounds and analytical standards
• Polypropylene housing construction delivers structural integrity to 87 psi maximum operating pressure with thermal stability to 60°C for diverse manufacturing conditions
• Dual Luer-Lok and Luer-Slip connections accommodate standard syringes without adapters, streamlining aseptic transfer procedures in pharmaceutical processing workflows
• Integrated polypropylene prefilter extends membrane lifetime by capturing coarse particulates upstream, reducing filter consumption in pharmaceutical sample applications

Pharmaceutical laboratories processing medium-volume organic samples require sterilization technology combining bacterial retention with chemical resistance. PVDF syringe filters deliver 0.22 µm sterile-grade performance through hydrophobic membrane chemistry. The solution provides performance reliability through validated microbial retention. Broad solvent compatibility supports drug manufacturing and analytical testing demanding efficient processing.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

14.5psi

Connection Type

Luer-Lok/Luer Slip

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

20ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

Yes

Prefilter Material

PP

Sterility

Sterile

Volume Throughput (ml)

50ml

Weight

0.88

Wetability

Hydrophobic

• HPLC Mobile Phase Sterilization - Provides bacteria-free organic and aqueous chromatography solvents for pharmaceutical analytical testing
• Pharmaceutical Formulation Sterilization - Sterilizes drug solutions in organic solvents for small-batch production and development applications
• Parenteral Solution Processing - Filters injectable pharmaceutical formulations requiring bacterial elimination in aseptic manufacturing environments
• Analytical Standard Sterilization - Removes microbial contamination from reference materials and calibration solutions for validated methods
• Organic Reagent Sterilization - Processes chemical solutions requiring microbial control in pharmaceutical manufacturing and research applications
• Microbiological Sample Preparation - Prepares sterile samples for microbial limit testing and bioburden analysis in regulatory compliance programs