Tisch
PVDF Syringe Filters w/ 3 Pre-Filters, 0.22 um, 25mm, 100/Pk SKU: SF18307

Polyvinylidene Fluoride (PVDF) Syringe Filters - SF18307

Pharmaceutical and environmental laboratories demand sterilization technology capable of processing highly particulate organic samples without premature membrane clogging, requiring multi-stage filtration that extends membrane lifetime while maintaining bacterial retention across aggressive solvent systems and challenging sample matrices. Advanced polyvinylidene fluoride membrane technology with 0.22 µm pore size and triple-layer prefilter system delivers validated bacterial elimination through progressive particle capture across glass fiber and polypropylene stages that protect the sterilizing membrane from fouling. Furthermore, the 25mm diameter configuration with 4.08 cm² filtration area enables efficient sterilization of 10-100 ml sample volumes, making this design ideal for pharmaceutical quality control and environmental testing applications requiring extended filter lifetime in high-particulate samples demanding both microbial control and chemical resistance.

Key PVDF Membrane Characteristics

• Hydrophobic surface requires pre-wetting with alcohols or compatible organic solvents before aqueous processing, optimizing performance for sterile organic pharmaceutical formulations
• 0.22 µm pore size provides sterile-grade filtration with validated bacterial retention, including Brevundimonas diminuta, ensuring microbial elimination for aseptic processing
• Exceptional chemical resistance withstands aggressive organic solvents, including chlorinated compounds, alcohols, ketones, and aromatic hydrocarbons across pharmaceutical workflows
• Low protein binding characteristics maintain the concentration of therapeutic proteins during sterile filtration, minimizing adsorption losses in biopharmaceutical applications
• Autoclave compatibility at 121°C with gamma sterilization capability provides contamination control options for aseptic pharmaceutical manufacturing environments

Key Construction Characteristics

• 100 µL holdup volume preserves samples by reducing retention within the housing, maximizing recovery of valuable pharmaceutical formulations and analytical compounds
• Polypropylene housing construction delivers structural integrity to 87 psi maximum operating pressure, providing reliable performance for pressurized sterilization systems
• Dual Luer-Lok and Luer-Slip connections integrate seamlessly with standard laboratory syringes without adapters, streamlining aseptic transfer procedures in manufacturing
• Triple-layer prefilter system with dual glass fiber and polypropylene stages captures coarse particulates progressively, dramatically extending membrane lifetime in challenging samples

Pharmaceutical and environmental laboratories processing particulate-laden samples require sterilization technology that combines bacterial retention with extended membrane lifetime and chemical resistance. PVDF syringe filters deliver 0.22 µm sterile-grade performance through triple-layer prefilter protection and hydrophobic membrane chemistry. Optimized for your challenging sample matrices, this filtration solution provides workflow efficiency with validated microbial retention, progressive particle capture for extended filter life, and broad solvent compatibility for pharmaceutical manufacturing, environmental testing, and quality control applications demanding both bacterial elimination and high dirt-loading capacity.

For more information about chemical and material compatibility, please review our Chemical Compatibility Chart.

Bubble Point (psi)

14.5psi

Connection Type

Luer-Lok/ Luer Slip

Diameter

25mm

Filtration Area

4.08cm²

Flow Rate

20ml

Holdup Volume

100μL

Material

Polyvinylidene Fluoride (PVDF)

Maximum Operating Pressure

87psi

Maximum Operating Temperature (°C)

60°C

Membrane Thickness (µm)

100-130μm

Pack Count

100

Pore Size (µm)

0.22

Prefilter (Yes/No)

Yes

Prefilter Material

GF+GF+PP

Sterility

Nonsterile

Sterilization

Autoclave at 121°C for 30min/ gamma 25kGy

Volume Throughput (ml)

50ml

Wetability

Hydrophobic

• Sterile HPLC Mobile Phase Preparation - Removes bacteria from organic chromatography solvents with extended filter life for high-particulate pharmaceutical samples
• Environmental Extract Sterilization - Sterilizes soil and sediment extracts in organic solvents, requiring particulate removal in environmental monitoring programs
• Pharmaceutical Formulation Processing - Filters viscous drug solutions and particulate-laden formulations requiring bacterial elimination with extended membrane lifetime
• Particulate-Laden Sample Sterilization - Processes challenging pharmaceutical samples requiring both bacterial retention and high dirt-loading capacity
• Organic Reagent Sterilizationv - Sterilizes chemical solutions and solvent mixtures with high particulate content in pharmaceutical manufacturing applications
• Industrial QC Testing - Filters viscous polymer solutions and resin formulations requiring sterile conditions in materials science quality control programs